Over the course of Wednesday, Harris is due to hold several further meetings on Capitol Hill to discuss Ireland’s economic, trade and foreign policy priorities.

Here, we have a look at the issues likely to dominate political discourse in the week to come

It comes as government ministers and businesses grapple with the 20 per cent tariffs imposed by US President Donald Trump.

Simon Harris held a late-night call with Howard Lutnick a number of weeks ago.

Tánaiste Simon Harris is set to pay a visit to the US next week as the fallout continues from Donald Trump's 'Liberation Day'

Senior figures in the Government have expressed hope for a negotiated settlement to mitigate the impact of US tariffs.

Micheál Martin said he is concerned about the impact on investments and jobs in Ireland, the EU and across the world.

In a statement, it highlighted a 450 per cent growth in the combined US and EU spirits sector under a tariff-free regime between 1997 and 2018.

His assessment came after US President Donald Trump announced that he was imposing a sweeping 20% tariff on imports from the EU.

But the industry, which accounts for a large portion of Irish exports, may be subjected to harsh tariffs later as the White House seeks to increase domestic production.

Donald Trump has said he will attempt to get US pharmaceutical companies back from Ireland

Tánaiste Simon Harris held a late-night call with US commerce secretary Howard Lutnick.

The Tánaiste has held a phone call with the US Secretary of Commerce.